Functional analysis of human T lymphotropic virus type 2 Tax proteins
Abstract Background The Tax proteins encoded by human T lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) are transcriptional activators Hobby boxes of both the viral long terminal repeat (LTR) and cellular promoters via the CREB and NFkB pathways.In contrast to HTLV-1, HTLV-2 has been classified into four distinct genetic subtypes A, B, C and